UAB Biosafety Manual

Download the full Biosafety ManualPDF file* as one PDF - 481 KB

Download each section individually below:

Note: only sections of the manual that are currently available are offered for download

    TABLE OF CONTENTS - 21 KBPDF file*

    1. Introduction - 14 KBPDF file*

    2. Program Administration - 53 KBPDF file*

      1. Office of the Vice President for Financial Affairs
      2. UAB Institutional Biosafety Committee
      3. The Department of Occupational Health & Safety
        1. Biosafety Division
        2. Biosafety Officer
      4. Deans/Department Chairs/Directors
      5. Principal Investigators/Laboratory Directors
      6. Laboratory Staff
      7. Liability Considerations
      8. Incidents of Non-compliance

    3. Project Registration

      1. New Project Registration
      2. Renewals
      3. Modifications of previously registered projects
      4. IBC/Biosafety Approval
      5. Appeal Process

    4. Principles of Biosafety - 33 KBPDF file*

      1. Containment
        1. Primary Containment (Safety Equipment)
        2. Secondary Containment (Facility Design)
      2. Basic Laboratory Safety
      3. Biosafety Levels - in brief

    5. Biohazards and Potentially Infectious Materials

      1. Definitions
      2. Potentially Infectious Materials Use
        1. Microbes
        2. Human Blood, Blood Products, Body Fluids and Tissues
        3. Tissue/Cell Culture
      3. Animal Use
        1. Minimum Biosafety Guidelines
        2. Infected Animals
        3. Use of Non-human Primates
      4. Recombinant DNA/RNA Use
        1. In the laboratory
        2. Human Gene Transfer (Therapy)
        3. Transgenic Animals
        4. Transgenic Plants
      5. Restricted Research Activities - 61 KBPDF file*
        1. Select Agents
        2. Attenuated Strains of Material on the Select Agents List
        3. Non-viable Agents on the Select Agents List
        4. Select Agent Toxin Exclusions
        5. Select Agents in Clinical or Diagnostic Samples
        6. Requesting Exemptions from the Select Agent Regulation
        7. Denial, Revocation, or Suspension of Registration
      6. Prohibited Research Activities

    6. Biosafety Containment Levels

      1. Laboratory Biosafety Level 1 (BSL-1)
      2. Laboratory Biosafety Level 2 (BSL-2)
      3. Laboratory Biosafety Level 3 (BSL-3)
      4. Laboratory Biosafety Level 4 (BSL-4)
      5. Animal Biosafety Level 1 (ABSL-1)
      6. Animal Biosafety Level 2 (ABSL-2)
      7. Animal Biosafety Level 3 (ABSL-3)
      8. Animal Biosafety Level 4 (ABSL-4)

    7. Biological Agents and Biohazard Classification - 45 KBPDF file*

      1. Risk Group 1 (RG1)
      2. Risk Group 2 (RG2)
      3. Risk Group 3 (RG3)
      4. Risk Group 4 (RG4)
      5. Restricted Animal Pathogens

    8. Administrative Controls

      1. Labels and Signs
      2. Laboratory Safety Plan (Standard Operating Procedures)
      3. Medical Surveillance
      4. Training
      5. Audits & Site Visits
      6. Visitors/Minors in the lab

    9. Engineering Controls

      1. Biological Safety Cabinets - 48 KBPDF file*
      2. Personal Protective Equipment
      3. Centrifuges
      4. Autoclaves
      5. Other Safety Equipment

    10. Work Practices

      1. Prudent Practices, Housekeeping, Hygiene
      2. Universal Precautions
      3. Syringes and Needles
      4. Use of Biological Safety Cabinets
      5. Blenders, Ultrasonic Disrupters, and Grinders
      6. Laundry
      7. Decontamination Procedures
      8. Tuberculosis and the Workplace - Respiratory Fit Testing

    11. Management of Biohazardous Materials

      [Under construction]

    12. Transportation of Biologic & Infectious Substances

      1. Within UAB
      2. Shipments From UAB
      3. Import and Export of Biological Materials
      4. Select Agent Transfer

    13. Emergency Response - 38 KBPDF file*

      1. Needlesticks and Exposures to Human Blood, Body Fluids, and Tissues
      2. Other Personal Injury
      3. Spill Response
      4. Other Emergencies

    APPENDICES

    1. UAB Biosafety Committee - 10 KBPDF file*
    2. UAB Employee Occupational Health Program - 43 KBPDF file*
    3. Exposure Control Plan Template - 71 KBPDF file*
    4. DOT Guide for Transporting Infectious Substances Safely - 1,696 KBPDF file*
    5. Properties of Common Disinfectants
    7. Project Registration - 201 KBPDF file*
    8. Registration for Recombinant DNA/RNA Research - 151 KBPDF file*
    9. Select Agent Program Registration
    10. UAB Medical Waste Management Plan - 38 KBPDF file*
    11. Herpesvirus Simiae (Herpes B) Guidelines
    12. Guidelines for Work with Vaccinia Vectors
    13. Guidelines for Work with Adenoviral Vectors

 

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